Antimonials in Experimental Infection of Mice

The use of antimony compounds, particularly potassium antimonyl tartrate (Tartar emetic), in Cryptococcosis has occasionally been mentioned in the literature,2"' but no experimental study of the therapeutic rationale of the use of antimonials in this infection has to our knowledge ever been under-taken. It did not seem that Tartar emetic was of any therapeutic value, but this should not reflect on the chemotherapeutic possibilities of the entire class of antimony derivatives. In rather extensive investigations on the therapeutic sensitivity of the chronic infection of mice with C. neoformans carried out in this laboratory it was observed that certain antimonials do indeed possess a marked effect in this otherwise resistant infection.